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N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide

PF-431396

CAS: 717906-29-1

Molecular Formula: C22H21F3N6O3S

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  5. N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide

N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide - Names and Identifiers

Name PF-431396
Synonyms PF431396
PF-431396
PF-431396 hydrate
N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide
N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide
N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate
N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396
CAS 717906-29-1

N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide - Physico-chemical Properties

Molecular FormulaC22H21F3N6O3S
Molar Mass506.5
Density1.506
Solubility Soluble in DMSO (50 mM).
Appearancepowder
Coloroff-white to blue-gray
pKa13.66±0.20(Predicted)
Storage Condition2-8°C
UseA dual inhibitor of FAK (focal adhesion kinase) and PYK2.
In vitro studyIn A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistent inhibit the increase in protein tyrosine phosphate (PY) induced by the evidence of added calcium and induced by W-7 in the presence.
In A20 cells, PF-431396 blocked anti-Ig- and aggregated LFA-1-induced tyrosine phosphorylation of Pyk2 with FAK and further blocked B- cell proliferation. PF-431396 continuously inhibits protein tyrosinase phosphorylation (PY) induced by calcium deficiency and W-7 induced in the presence of calcium.

N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide - Risk and Safety

Hazard SymbolsT - Toxic
Toxic
Risk CodesR25 - Toxic if swallowed
R36 - Irritating to the eyes
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDsUN 2811 6.1 / PGIII
WGK Germany3

N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide - Introduction

The PF-431396 is a double PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively.
Last Update：2022-10-16 17:41:48

N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide - Reference Information

biological activity PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively.
PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively.
In vitro study In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phoning of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistent inhibit the increase in protein tyrosine phosphate (PY) induced by the evidence of added calcium and induced by W-7 in the presence.
In A20 cells, PF-431396 blocked anti-Ig- and aggregated LFA-1 induced P yk2 phosphorylates tyrosine with FAK and further blocks B cell proliferation. PF-431396 continuously inhibits protein tyrosinase phosphorylation (PY) induced by calcium deficiency and W-7 induced in the presence of calcium.
Target TargetValue FAK 2 nM PYK2 11 nM
TargetValue
FAK 2 nM
PYK2 11 nM
Last Update：2024-04-09 21:21:28
N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide
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MedChemExpress (MCE)
Spot supply
Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
BOC Sciences
Spot supply
Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide
1185297-02-2
Biscrotonic acid 2-(hydroxymethyl)propane-1,3-diyl ester
Nonanedioic acid, ester with 1,4-butanediol
4-硝基苯乙烯
Glyceraldehyde, D-
1,2-Cyclohexanedicarboxamide
EINECS 210-428-1
17-phenyl trinor Prostaglandin F2α methyl ester
5-溴-1-甲基-1H-吲唑
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